The ESP Guitar Company

Does it sound dead when the guitar isn't plugged in, or only when run through an amp?

If it's bad at all times, replacing the block could help. I'd definitely look at the nut and the bridge surface as well. You might also look into lowering your pickup heights a bit. The magnetic field could be interfering with the the string vibration (though that usually affects every string).

If it's only when it's plugged in, check the height of the pickup (raise it instead of lowering it), and see if there might be some dirt and rust on the pole pieces which could also cause problems.

Have you tried other string gauges? You didn't specify. Just throwing a (most likely stupid) question/thought out there.

Thanks Pus. It seems like it could be dead unplugged, but it's hard to tell. I'm going to give it a fresh listen in the morning, maybe I'll try playing with the picku height. It's an emg 81 btw.

I have not tried other string gauges. If all else fails I guess I may try that, but it seems unlikely for that to be the problem.

Thanks guys

Check to see if the string is getting choked somewhere, or isn't making good contact with the nut/bridge surface.

You might also consider replacing the entire saddle on the Floyd.