I'm all about that high gain!
I do not like one distortion completely saturate my amplifier generating a lot of noise
I really love the sound of the ENGL Fireball and the famous Mesa/Boogie dual rectifier. Those two amps are a great example of the Modern high-gain distortion I love.
hmmm, yeah this is a difficult one in all honesty, there are also so many factors. some that depend on the instrument and it's pickups as well.
Really hard to vote...