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The most common side effect of Metformin Hcl 500 Mg is gastrointestinal discomfort, including symptoms such as nausea, vomiting, diarrhea, and abdominal pain. These side effects typically occur during the initial stages of treatment and may improve over time or with dosage adjustments. In rare cases, Metformin Hydrochloride 500 Mg can also cause lactic acidosis, a serious condition characterized by the buildup of lactic acid in the bloodstream, particularly in individuals with kidney or liver impairment. It's important for patients taking metformin to monitor for signs of lactic acidosis, such as weakness, muscle pain, difficulty breathing, and unusual tiredness, and to seek medical attention if these symptoms occur.