Just another quick note about the suggested Maxon 808. I did not realize so many players use it. Found this on the Maxon site.
Perhaps I'm a bit strange, but my lead tone is actually less gainy and more mid heavy than my rhythm tone.
+1 on the mids.
I use around the same amount of gain.
The Vintage mode on Rectos sounds great for leads, IMO.
A lot more mids, a lot less bass, and just a touch less treble than rythm tone is what I usually go for.