Depends on taste, I have one set to high gain and alot of bass and treb and 12 olclock mids and lower volume. Then on the triple rect, I reduce the gain and bass and treb just a bit and jack the volume as it is 150wts. If you jack the gain on both it can get noisy. Basically this give you never ending sustain but still alot of noise and my noise gate helps alot. I run than into a mesa 4x12 and out of the mesa 4x12 in a marshall 4x12.