The ESP Guitar Company

Ive been trying to find the best strings to fit my style, i like a beefy low end and easy to play higher end. Right now I am using DDT 54 to 12, but the high three strings are very hard to bend and wirey, and the low strings make noise when i slide,, Ive tired daddario, thought they were to crisp and not beefy for my styel slinkys just didn't like Dunlop: I liked the drop down edition but not in love with them what would you recommend ? if my guitar is tuned and setup to 54 to 12 does that mean i have to have it re set up if i go down to 10s? id probl like to go no lower than 52 to 10......